私はメタアナリシスでよく、重症度評価からの脱落人数をAcceptabilityの代替指標として用いています。そこを査読で突っ込まれました。少しまとめてみたので共有します。

Acceptability is an important aspect of healthcare interventions’ assessment, but it is not well defined. (Sekhon et al., 2017) We used the dropouts from assessment for any reason as a proxy measure for acceptability, because it encompasses both efficacy and burden of the intervention, and is used for major network meta-analyses in the field of MDD. (Cipriani et al., 2018; Cuijpers et al., 2021) It is also practical in a sense that we can extract the number from most studies. When the number of dropouts from assessment was not clearly stated, we used the value obtained by subtracting the number of participants at measurement from the number of participants randomized. 

• Cipriani, A., Furukawa, T.A., Salanti, G., Chaimani, A., Atkinson, L.Z., Ogawa, Y., Leucht, S., Ruhe, H.G., Turner, E.H., Higgins, J.P., Egger, M., Takeshima, N., Hayasaka, Y., Imai, H., Shinohara, K., Tajika, A., Ioannidis, J.P., Geddes, J.R., 2018. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. https://doi.org/10.1016/s0140-6736(17)32802-7 

• Cuijpers, P., Quero, S., Noma, H., Ciharova, M., Miguel, C., Karyotaki, E., Cipriani, A., Cristea, I.A., Furukawa, T.A., 2021. Psychotherapies for depression: a network meta‐analysis covering efficacy, acceptability and long‐term outcomes of all main treatment types. World Psychiatry 20, 283–293. https://doi.org/10.1002/wps.20860 

• Sekhon, M., Cartwright, M., Francis, J.J., 2017. Acceptability of healthcare interventions: an overview of reviews and development of a theoretical framework. BMC Heal. Serv. Res. 17, 88. https://doi.org/10.1186/s12913-017-2031-8